Properties of tug-of-war model for cargo transport by molecular motors

Molecular motors are essential components for the biophysical functions of the cell. Our current quantitative understanding of how multiple motors move along a single track is not complete; even though models and theories for single motor chemomechanics abound. Recently, M.J.I. M$\ddot{\rm u}$ller {\em et al.} have developed a tug-of-war model to describe the bidirectional movement of the cargo (PNAS(2008) 105(12) P4609-4614). Through Monte Carlo simulations, they discovered that the tug-of-war model exhibits several qualitative different motility regimes, which depend on the precise value of single motor parameters, and they suggested the sensitivity can be used by a cell to regulate its cargo traffic. In the present paper, we carry out a thorough analysis of the tug-of-war model. All the stable, i.e., biophysically observable, steady states are obtained. Depending on several parameters, the system exhibits either uni-, bi- or tristability. Based on the separating boundary of the different stable states and the initial numbers of the different motor species that are bound to the track, the steady state of the cargo movement can be predicted, and consequently the steady state velocity can be obtained. It is found that, the velocity, even the direction, of the cargo movement change with the initial numbers of the motors which are bound to the track and several other parameters

Hadron Mass Spectrum from Lattice QCD

Finite temperature lattice simulations of quantum chromodynamics (QCD) are sensitive to the hadronic mass spectrum for temperatures below the "critical" temperature T_c ~ 160 MeV. We show that a recent precision determination of the QCD trace anomaly shows evidence for the existence of a large number of hadron states beyond those known from experiment. The lattice results are well represented by an exponentially growing hadron mass spectrum up to a temperature T = 155 MeV. Using simple parametrizations we show how one may estimate the total spectral weight in these yet undermined states

JPEG2000 Image Compression on Solar EUV Images

For future solar missions as well as ground-based telescopes, efficient ways to return and process data have become increasingly important. Solar Orbiter, e.g., which is the next ESA/NASA mission to explore the Sun and the heliosphere, is a deep-space mission, which implies a limited telemetry rate that makes efficient onboard data compression a necessity to achieve the mission science goals. Missions like the Solar Dynamics Observatory (SDO) and future ground-based telescopes such as the Daniel K. Inouye Solar Telescope, on the other hand, face the challenge of making petabyte-sized solar data archives accessible to the solar community. New image compression standards address these challenges by implementing efficient and flexible compression algorithms that can be tailored to user requirements. We analyse solar images from the Atmospheric Imaging Assembly (AIA) instrument onboard SDO to study the effect of lossy JPEG2000 (from the Joint Photographic Experts Group 2000) image compression at different bit rates. To assess the quality of compressed images, we use the mean structural similarity (MSSIM) index as well as the widely used peak signal-to-noise ratio (PSNR) as metrics and compare the two in the context of solar EUV images. In addition, we perform tests to validate the scientific use of the lossily compressed images by analysing examples of an on-disk and off-limb coronal-loop oscillation time-series observed by AIA/SDO.Comment: 25 pages, published in Solar Physic

“Though this be madness, yet there is method in’t.” A counterfactual analysis of Richard Wagner’s Tannhäuser

Much like Wagner himself, the eponymous hero of Tannhäuser treads a path of stark contrasts and rapid swings. From Wartburg to the Venusberg and to the Vatican, the gifted bard transforms from self-centered artist to seduced disciple, disillusioned devotee, hopeful lover, self-loathing pilgrim and finally redeemed martyr. He tries everything and everything is trying. These contrasts reach a peak in the opera‟s central episode, the song contest at Wartburg. Tannhäuser has just been welcomed at the court, received Elisabeth‟s favor and affection, and is ready to compete for the contest‟s prize, one as lofty as possibly the princess‟ hand. Instead of securing his reintegration to Wartburg with a brilliant performance, however, he spoils the event with insolent remarks and the exhibitionist disclosure of his Venusberg experience. His behavior offends his peers, scandalizes the court, breaks Elisabeth‟s heart, and brings him to the edge of death. Why would Tannhäuser sacrifice everything for nothing

Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors

Intracellular transport is based on molecular motors that pull cargos along cytoskeletal filaments. One motor species always moves in one direction, e.g. conventional kinesin moves to the microtubule plus end, while cytoplasmic dynein moves to the microtubule minus end. However, many cellular cargos are observed to move bidirectionally, involving both plus-end and minus-end directed motors. The presumably simplest mechanism for such bidirectional transport is provided by a tug-of-war between the two motor species. This mechanism is studied theoretically using the load-dependent transport properties of individual motors as measured in single-molecule experiments. In contrast to previous expectations, such a tug-of-war is found to be highly cooperative and to exhibit seven different motility regimes depending on the precise values of the single motor parameters. The sensitivity of the transport process to small parameter changes can be used by the cell to regulate its cargo traffic.Comment: 17 pages, latex, 11 figures, 4 tables, includes Supporting Informatio

Microscopic formula for transport coefficients of causal hydrodynamics

The Green-Kubo-Nakano formula should be modified in relativistic hydrodynamics because of the problem of acausality and the breaking of sum rules. In this work, we propose a formula to calculate the transport coefficients of causal hydrodynamics based on the projection operator method. As concrete examples, we derive the expressions for the diffusion coefficient, the shear viscosity coefficient, and corresponding relaxation times.Comment: 4 pages, title was modified, final version published in Phys. Rev.

Geometric quantum gates with superconducting qubits

We suggest a scheme to implement a universal set of non-Abelian geometric transformations for a single logical qubit composed of three superconducting transmon qubits coupled to a single cavity. The scheme utilizes an adiabatic evolution in a rotating frame induced by the effective tripod Hamiltonian which is achieved by longitudinal driving of the transmons. The proposal is experimentally feasible with the current state of the art and could serve as a first proof of principle for geometric quantum computing.Comment: 7 pages, 5 figure

Butterfly hysteresis loop and dissipative spin reversal in the S=1/2, V15 molecular complex

Time resolved magnetization measurements have been performed on a spin 1/2 molecular complex, so called V$_{15}$. Despite the absence of a barrier, magnetic hysteresis is observed over a timescale of several seconds. A detailed analysis in terms of a dissipative two level model is given, in which fluctuations and splittings are of same energy. Spin-phonon coupling leads to long relaxation times and to a particular "butterfly" hysteresis loop.Comment: LaTeX/RevTeX, 3 figures.Approved for publication in PR